Oral Hypoglycemic Drugs



Hypoglycemia in diabetics on oral hypoglycemic drugs is much less common than in insulin-treated diabetic patients. Long-acting oral hypoglycemic agents such as chlorpropamide are more frequently associated with hypoglycemia than are short-acting agents such as tolbutamide. Severe hypoglycemia sec­ondary to oral hypoglycemic agents occurs most commonly in patients who abuse ethanol or have renal or hepatic disease.
The surreptitious use of oral hypoglycemic agents can induce hypoglycemia in nondiabetics. In these cases, the insulin and C-peptide mea­surements are identical to those seen in patients with insulinomas. When oral agents are suspected as the cause of hypoglycemia in nondiabetics, either blood or urine should be assayed for the presence of these drugs.




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